Read e-book online The Vital Few: The Entrepreneur and American Economic PDF

By Jonathan Hughes

ISBN-10: 0195040384

ISBN-13: 9780195040388

The very important Few, a examine of the contribution of marketers to the yank financial system, presents graphics of the boys and girls whose person company has helped to set up the nature of the yankee businessperson and to hold our economic system ahead from colonial instances. studying such mythical figures as William Penn, Eli Whitney, Henry Ford, and J. Pierpont Morgan of their social and fiscal setting, Jonathan Hughes illuminates every one interval of yank monetary historical past and gives insights into the workings of yank company and the certain characteristics required of its super-achievers. making an allowance for such dramatic adjustments within the economic climate because the explosive development of presidency and the difficult results of "stagflation," Hughes has now multiplied his unique quantity. the hot version comprises extra biographies and a brief essay at the nature of paperwork in either the govt and the non-public region. either biographies are of "bureaucratic entrepreneurs", whose paintings within the federal executive represents the 2 so much widespread traits in govt economics. Mary Switzer's 48-year occupation demonstrates the ways that the fashionable welfare nation has built. First a catalyst then a tremendous strength in setting up social courses and associations, she is largely chargeable for the lifestyles of the yankee welfare nation. Marriner Eccles's occupation, however, indicates the evolution of "compensatory" economic and financial regulations from the hot Deal to the Korean conflict. A self-made millionaire who used to be appointed to a high-level activity within the federal executive, Eccles hand over his publish after 1950, confident that American fiscal coverage used to be hopelessly inflationary and economically damaging. With those new additions, The important Few, lengthy a resource of thought and monetary curiosity, is extra available and priceless than ever.

Show description

Read more

Problems in Quantum Mechanics: with Solutions by Emilio d'Emilio, Luigi E. Picasso PDF

By Emilio d'Emilio, Luigi E. Picasso

ISBN-10: 3319532669

ISBN-13: 9783319532660

ISBN-10: 3319532677

ISBN-13: 9783319532677

This moment version of an incredibly well-received e-book offers greater than 250 nonrelativistic quantum mechanics difficulties of various trouble with the purpose of delivering scholars didactic fabric of confirmed worth, permitting them to attempt their comprehension and mastery of every topic. The assurance is intensely wide, from issues regarding the problem of classical physics via achievements in the framework of recent atomic physics to full of life debated, exciting facets when it comes to, for instance, the EPR paradox, the Aharonov-Bohm influence, and quantum teleportation. in comparison with the 1st version, quite a few advancements were made and extra themes of curiosity incorporated, in particular concentrating on straightforward strength scattering. the issues themselves variety from regular and easy ones to people who are complicated yet should be thought of crucial simply because they deal with questions of exceptional significance or features quite often ignored in primers. The booklet bargains scholars either a superb instrument for self sufficient studying and a ready-reference advisor they could go back to later of their careers.

Show description

Read more

Medical Pharmacology and Therapeutics, 4e by Derek G. Waller BSc DM MBBS FRCP, Tony Sampson MA PhD PDF

By Derek G. Waller BSc DM MBBS FRCP, Tony Sampson MA PhD FHEA FBPharmacolS

ISBN-10: 0702051802

ISBN-13: 9780702051807

The fourth version of Medical Pharmacology and Therapeutics offers an entire foundation for studying approximately secure and powerful prescribing of contemporary drugs. It deals all of the pharmacology scientific scholars will desire - from uncomplicated technology pharmacology and pathophysiology, via to scientific pharmacology and therapeutics, in accordance with cutting-edge built-in curricula. The disease-based strategy and transparent presentation of ways medicines are utilized in medical perform units it except different texts and is helping make it such a useful advisor for all health and wellbeing execs from the beginning in their path until eventually once they have certified.

This new version has been widely revised and up-to-date all through. Key positive aspects comprise:

¦ Succinct reasons of the foremost pathogenic mechanisms of every disorder and consequent scientific symptoms

¦ complete stories of significant drug sessions correct to every sickness

¦ A based method of the foundations of ailment administration - outlining middle ideas of drug selection and making plans a healing routine for universal diseases

¦ Quick-reference drug compendia, which illustrate key similarities and alterations between medicinal drugs in every one classification

¦ New sections on key and evolving themes, together with headache and drug remedy in palliative care

¦ Re-worked artwork programme to extra make clear advanced areas

¦ absolutely revised self-assessment questions and case-based workouts - to check knowing and relief revision

  • Integrates uncomplicated technology pharmacology, scientific pharmacology and therapeutics
  • Brief evaluation of pathophysiology of significant diseases
  • Case histories and self-assessment questions (and answers)
  • Tabular presentation of all universal medicinal drugs inside every one class
  • Section on additional reading
  • Includes extra on genetic issues
  • Drug tables made extra concise to make info extra accessible
  • Fully up to date to mirror present medical practice

Show description

Read more

Read e-book online High Content Screening: Science, Techniques and Applications PDF

By Steven A. Haney

ISBN-10: 047003999X

ISBN-13: 9780470039991

ISBN-10: 0470229861

ISBN-13: 9780470229866

The authoritative reference on HCS in organic and pharmaceutical research

excessive content material Screening (HCS) has been a number one method in toxicology reviews for years. fresh advances have broadened the diversity of functions to surround new components. excessive content material Screening: technological know-how, recommendations, and purposes presents accomplished insurance of HCS in 4 sections:
*

the fundamentals of HCS, from the definition to exact discussions of part technologies
*

Examples of HCS utilized in organic purposes and early drug discovery, with an emphasis on functions in oncology and neuroscience
*

using HCS around the drug improvement pipeline
*

information administration, facts research, and structures biology, with guidance for utilizing the big datasets generated through HCS in systems-level studies

With chapters contributed by means of major experts from academia and undefined, this advisor covers:
*

a variety of issues, together with assay improvement, telephone tradition, snapshot processing, robotics, database structure and administration, version structures for research, and more
*

targeted discussions on imaging in 3D, imaging of tissues for pharmacodynamic experiences, and screening of either small molecule and RNAi libraries via HCS
*

the jobs of bench researchers and IT body of workers in enforcing and retaining HCS platforms
*

The demanding situations and benefits of utilizing HCS this day, and a glance at destiny directions

With eighty-seven distinctive figures readers can consult with in complete colour at the accompanying CD-ROM, this is often the premiere, hands-on reference on HCS for researchers in academia, biotechnology, and pharmaceutical businesses. it is also a very good source for lab managers and graduate scholars in biochemistry, mobilephone biology, toxicology, and comparable fields.Content:
Chapter 1 drawing close excessive content material Screening and research: functional recommendation for clients (pages 1–24): Scott Keefer and Joseph Zock
Chapter 2 computerized excessive content material Screening Microscopy (pages 25–42): Paul A. Johnston
Chapter three A Primer on snapshot Informatics of excessive content material Screening (pages 43–84): Xiaobo Zhou and Stephen T. C. Wong
Chapter four constructing strong excessive content material Assays (pages 85–109): Arijit Chakravarty, Douglas Bowman, Jeffrey A. Ecsedy, Claudia Rabino, John Donovan, Natalie D'Amore, Ole Petter Veiby, Mark Rolfe and Sudeshna Das
Chapter five HCS in mobile Oncology and Tumor Biology (pages 111–143): Steven A. Haney, Jing Zhang, Jing Pan and Peter LaPan
Chapter 6 Exploring the total strength of mixing excessive Throughput RNAi with excessive content material Readouts: From objective Discovery displays to Drug Modifier reports (pages 145–168): Christoph Sachse, Cornelia Weiss?Haljiti, Christian Holz, Kathrin Regener, Francoise Halley, Michael Hannus, Corina Frenzel, Sindy Kluge, Mark Hewitson, Benjamin Bader, Amy Burd, Louise Perkins, Alexander Szewczak, Stefan Prechtl, Claudia Merz, Peter Rae, Dominik Mumberg and Christophe J. Echeverri
Chapter 7 Leveraging HCS in Neuroscience Drug Discovery (pages 169–187): Myles Fennell, Beal McIlvain, Wendy Stewart and John Dunlop
Chapter eight dwell mind Slice Imaging for extremely excessive content material Screening: computerized Fluorescent Microscopy to review Neurodegenerative illnesses (pages 189–204): O. Joseph Trask, C. Todd DeMarco, Denise Dunn, Thomas G. Gainer, Joshua Eudailey, Linda Kaltenbach and Donald C. Lo
Chapter nine excessive content material research of Human Embryonic Stem telephone development and Differentiation (pages 205–224): Paul J. Sammak, Vivek Abraham, Richik Ghosh, Jeff Haskins, Esther Jane, Patti Petrosko, Teresa M. Erb, Tia N. Kinney, Christopher Jefferys, Mukund Desai and Rami Mangoubi
Chapter 10 HCS for HTS (pages 225–247): Ann F. Hoffman and Ralph J. Garippa
Chapter eleven the jobs of excessive content material mobile Imaging in Lead Optimization (pages 249–268): Jonathan A. Lee, Karen Cox, Aidas Kriauciunas and Shaoyou Chu
Chapter 12 utilizing excessive content material research for Pharmacodynamic Assays in Tissue (pages 269–291): Arijit Chakravarty, Douglas Bowman, Kristine Burke, Bradley Stringer, Barbara Hibner and Katherine Galvin
Chapter thirteen excessive content material research of Sublethal Cytotoxicity in Human HepG2 Hepatocytes for Assessing power and Mechanism for Chemical? and Drug?Induced Human Toxicity (pages 293–316): Peter J. O'Brien
Chapter 14 Open dossier codecs for prime content material research (pages 317–328): Jason R. Swedlow, Curtis Rueden, Jean?Marie Burel, Melissa Linkert, Brian Loranger, Chris Allan and Kevin W. Eliceiri
Chapter 15 research of Multiparametric HCS information (pages 329–354): Andrew A. Hill, Peter LaPan, Yizheng Li and Steven A. Haney
Chapter sixteen Quantitative and Qualitative mobile Genomics: excessive content material research as an finish element for HT?RNAi Phenotype Profiling utilizing GE's IN phone Platform (pages 355–369): David O. Azorsa, Christian Beaudry, Kandavel Shanmugam and Spyro Mousses
Chapter 17 optimum features of Protein–Protein interplay Biosensors for mobile structures Biology Profiling (pages 371–387): Kenneth A. Giuliano, Daniel R. Premkumar and D. Lansing Taylor

Show description

Read more

New PDF release: Handbook of Assay Development in Drug Discovery (Drug

By Lisa K. Minor

ISBN-10: 1574444719

ISBN-13: 9781574444711

The necessity to monitor ambitions speedier and extra successfully, coupled with advances in parallel and multiplex chemical synthesis, has contributed to the expanding use of multiwell assays for drug discovery. The Handbook of Assay improvement in Drug Discovery is a reference that describes the full armament of instruments at the moment to be had for appearing a number of assay ideas.

Featuring contributions from assay builders within the pharmaceutical and seller groups, the ebook provides descriptions of tools, laboratory guidance and protocols used to accomplish such tools, particular examples of every assay process, and troubleshooting instruments. The instruction manual describes biochemical assay periods in addition to non-class particular assay improvement for cell-based assays. It covers a variety of objective classes—including kinases, proteases, nuclear receptors, and GPCRs—and describes at the moment hired equipment and assay forms, resembling radioligand binding assays, snapshot research assays, enzyme fragment complementation, and bioluminescent and fluorescent-based assays.

Designed as a advisor to operating an assay from begin to end, the Handbook of Assay improvement in Drug Discovery is a fantastic bench best better half for discovery researchers, laboratory managers, teachers, and different scientists curious about drug discovery screening, lead profiling, healing goal review, and assay improvement and implementation within the pharmaceutical and biotechnology industries.

Daniel E. Levy, editor of the Drug Discovery Series, is the founding father of DEL BioPharma, a consulting carrier for drug discovery courses. He additionally continues a weblog that explores natural chemistry.

Show description

Read more

Download e-book for kindle: Structure-Based Ligand Design by Kenneth M. Merz, Dagmar Ringe, Charles H. Reynolds

By Kenneth M. Merz, Dagmar Ringe, Charles H. Reynolds

ISBN-10: 3527293434

ISBN-13: 9783527293438

ISBN-10: 3527612173

ISBN-13: 9783527612178

So much medicines bind to a in actual fact outlined macromolecular aim that's complementary by way of constitution and chemistry. This statement is the elemental paradigm of structure-based ligand layout. even though this technique first emerged within the Eighties, it has already develop into a strong software for pharmaceutical study. a lot has been realized, even if, because the first makes an attempt to find medicines at the foundation of obtainable biochemical and structural facts. these days, structure-based ligand layout is a longtime strategy for growing medications with new structural gains, for editing binding actions and pharmacokinetic homes, and for elucidating binding modes and structure-activity relationships.

This quantity provides the underlying ideas of the strategy and highlights real-life purposes similar to the invention of HIV-protease inhibitors. It indicates that structure-based ligand layout has many benefits over different extra conventional ways to designing new medications, offering it's hired correctly and with an intensive wisdom of the pitfalls to avoid.

the easy presentation and huge record of references to the unique literature in addition to a number of colour figures illustrating structural relationships make this quantity an quintessential software for each scientist operating within the sector of drug discovery. Content:
Chapter 1 Rational layout of Bioactive Molecules (pages 1–13): okay. Gubernator and H.?J. Bohm
Chapter 2 Examples of energetic parts of constitution Based?Design (pages 15–36): okay. Gubernator and H.?J. Bohm
Chapter three Structure?Based layout: From Renin to HIV?1 Protease (pages 37–71): Elizabeth A. Lunney and Christine Humblet
Chapter four Zinc Endoproteases: A Structural Superfamily (pages 73–88): N. Borkakoti
Chapter five Structure?Based layout of powerful Beta?Lactamase Inhibitors (pages 89–103): okay. Gubernator, I. Heinze?Krauss, P. Angehrn, R. L. Charnas, C. Hubschwerlen, C. Oefner, M.G.P. web page and F. okay. Winkler
Chapter 6 Inhibition of Sialidase (pages 105–119): Neil R. Taylor
Chapter 7 Rational layout of Inhibitors of HIV?1 opposite Transcriptase (pages 121–127): Wolfgang Schafer
Chapter eight New Computational methods to foretell Protein?Ligand Interactions (pages 129–142): Hans?Joachim Bohm
Chapter nine the way forward for Structure?Based layout: A useful principle? (pages 143–147): H.?J. Bohm and okay. Gubernator

Show description

Read more

Download PDF by Nicholas Everett: The Alphabet of Galen: Pharmacy from Antiquity to the Middle

By Nicholas Everett

ISBN-10: 080209550X

ISBN-13: 9780802095503

The Alphabet of Galen is a serious variation and English translation of a textual content describing, in alphabetical order, approximately 300 ordinary items - together with metals, aromatics, animal fabrics, and herbs - and their medicinal makes use of. A Latin translation of past Greek writings on pharmacy that experience no longer survived, it circulated between collections of 'authorities' on drugs, together with Hippocrates, Galen of Pergamun, Soranus, and playstation . Apuleius.

This paintings provides attention-grabbing linguistic good points, together with differently unattested Greek and Latin technical phrases and designated pharmacological descriptions. Nicholas Everett offers a window onto the medieval translation of old

science and medieval conceptions of pharmacy. With a finished scholarly equipment

and a contextual creation, The Alphabet of Galen is an enormous source for

understanding the richness and variety of clinical history.

Show description

Read more

Download PDF by C. Robin Ganellin, Roy Jefferis, Stanley M. Roberts: Introduction to Biological and Small Molecule Drug Research

By C. Robin Ganellin, Roy Jefferis, Stanley M. Roberts

ISBN-10: 0123971764

ISBN-13: 9780123971760

Introduction to organic and Small Molecule Drug study and improvement provides, for the 1st time, an advent to the technological know-how at the back of winning pharmaceutical examine and improvement courses. The e-book explains easy ideas, then compares and contrasts methods to either biopharmaceuticals (proteins) and small molecule medicinal drugs, providing an summary of the company and administration problems with those methods. The latter a part of the e-book presents rigorously chosen real-life case reviews illustrating how the speculation awarded within the first a part of the ebook is de facto positioned into perform. reviews contain Herceptin/T-DM1, erythropoietin (Epogen/Eprex/NeoRecormon), anti-HIV protease inhibitor Darunavir, and more.

Introduction to organic and Small Molecule Drug learn and Development is meant for late-stage undergraduates or postgraduates learning chemistry (at the biology interface), biochemistry, medication, pharmacy, drugs, or allied topics. The booklet is usually valuable in a large choice of technology measure classes, in post-graduate taught fabric (Masters and PhD), and as uncomplicated history interpreting for scientists within the pharmaceutical industry.

  • For the 1st time, the elemental clinical ideas of biopharmaceuticals and small molecule chemotherapeutics are mentioned side-by-side at a easy level
  • Edited by way of 3 senior scientists with over a hundred years of expertise in drug learn who've compiled the easiest clinical comparability of small molecule and biopharmaceuticals ways to new drugs
  • Illustrated with key examples of vital medicinal drugs that exemplify the fundamental rules of pharmaceutical drug study and development

Show description

Read more

Good design practices for GMP pharmaceutical facilities by Terry Jacobs, Andrew A. Signore PDF

By Terry Jacobs, Andrew A. Signore

ISBN-10: 1315355027

ISBN-13: 9781315355023

ISBN-10: 1482258900

ISBN-13: 9781482258905

This revised ebook serves as a convenient and present reference for execs engaged in making plans, designing, construction, validating and protecting sleek cGMP pharmaceutical production amenities within the U.S. and the world over. the hot version expands on facility making plans, with a spotlight at the ever-growing have to regulate current legacy amenities, and on present traits in pharmaceutical production which come with techniques for sustainability and LEED construction rankings. All chapters were re-examined with a clean outlook on present sturdy layout practices.

Show description

Read more

Download e-book for kindle: Pocket Prescriber by Timothy RJ Nicholson, Donald RJ Singer

By Timothy RJ Nicholson, Donald RJ Singer

ISBN-10: 1444121871

ISBN-13: 9781444121872

A brand new annual version of this renowned pocket drug consultant. it really is totally up-to-date with the inclusion of recent medicines and with outdated medications being got rid of. It offers the main crucial scientific pharmacology info that busy clinicians want by means of concentrating on the main commone 500 pharmaceuticals.

Show description

Read more